A case of cutaneous necrosis during interferon-beta 1b (B-IFN) therapy in multiple sclerosis.
نویسندگان
چکیده
منابع مشابه
Application of Interferon Beta-1b in Multiple Sclerosis
Recombinant interferon beta-1b (IFNβ-1b) was the first approved disease-modifying therapy for patients with multiple sclerosis (MS) by the world regulatory agencies for medical drugs and devices. IFNβ-1b significantly decreases the inflammatory component of MS but still has doubtable effect on the neurodegenerative component. This article appraises the beneficial effects of IFNβ-1b on clinical ...
متن کاملCutaneous and pulmonary sarcoidosis following treatment of multiple sclerosis with interferon-β-1b: a case report
INTRODUCTION Several cases of sarcoidosis following treatment with interferon-α have been reported in the literature, but those following interferon-β are very rare. We report the case of a patient with multiple sclerosis who developed pulmonary and cutaneous sarcoidosis following treatment with Betaseron® (interferon-β-1b). CASE PRESENTATION A 33-year-old Caucasian woman with a history of mu...
متن کاملNeutralizing antibodies (NABS) and interferon beta-1b therapy of multiple sclerosis.
Biological drugs that have a protein or peptide structure provide new and highly eff e c t i v e therapies for a number of conditions and diseases, but their prolonged use in patients gives rise to new problems and questions, amongst them the possible occurrence of neutralizing antibodies (Nabs). We discuss some aspects of this particular problem in relation to interferon-beta therapy of multip...
متن کاملUrinary myelin basic protein-like material in patients with multiple sclerosis during interferon beta-1b treatment.
OBJECTIVES To determine levels of urinary myelin basic protein-like material (MBPLM) in patients with multiple sclerosis (MS) openly treated with interferon beta-1b and to correlate these with clinical changes. BACKGROUND Levels of urinary MBPLM correlate with the presence of the progressive phase of MS and with the disease burden detected on T2-weighted, cranial magnetic resonance imaging. M...
متن کاملAcute acneiform eruption induced by interferon beta-1b during treatment for multiple sclerosis.
Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomodulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application ...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1997
ISSN: 0022-3050
DOI: 10.1136/jnnp.62.4.418